| Life Science Frontier | Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes
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| Life Science Frontier | Efficacy and safety of garetosmab, an activin A-blocking antibody, in fibrodysplasia ossificans progressiva (OPTIMA): a randomised, double-blind, placebo-controlled, phase 3 trial
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| Metabolism & Aging | Prediabetes subtype-based stratification reveals distinct long-term risks for type 2 diabetes
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| Food, Nutrition & Regulation | Exploring the functionality of chickpea flour fermented by lactic acid bacteria: a multidisciplinary approach for ingredient development
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| Life Science Frontier | A phenome-wide structural variant map from 467,152 UK Biobank genomes
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| Life Science Frontier | Lonvoguran Ziclumeran — In Vivo CRISPR Gene Editing in Hereditary Angioedema
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| Life Science Frontier | A microexon regulatory code reveals autism-linked genetic variation
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| Metabolism & Aging | An NAD+-responsive adipose signal coordinates inter-organ defense against muscle atrophy
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| Natural Products | Enzyme discovery opens a new route to natural UV-absorbing saclipins (논문: Lipoxygenase AsLOX2 Catalyzes the Gateway Oxygenation Step in the Biosynthesis of the UV-Absorbing Oxylipin Saclipin in the Edible Cyanobacterium Aphanothece sacrum)
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| Food, Nutrition & Regulation | Health Risks of Cyanotoxin Contamination in Dietary Supplements: Mechanistic Insights into Organ-Specific Toxicity
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| Food, Nutrition & Regulation | Exploring Socioeconomic Disparities: The Association between the Mediterranean Lifestyle and Mortality across Education and Income Levels in the Prospective Lifelines Cohort
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| Life Science Frontier | The human gut microbiome primes fever after vaccination
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| Life Science Frontier | A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis
Yu Q, Kim H, Seidel S, … Qiu C, Shendure J · Science · DOI 10.1126/science.ael0508 | KO |
| Life Science Frontier | Human lung organoid modelling of tissue-resident antiviral T cell responses
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| Metabolism & Aging | Longer lipids mark aging and constrain lifespan
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| Metabolism & Aging | Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial
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| Metabolism & Aging | Cardiovascular safety of orforglipron versus insulin glargine in adults with type 2 diabetes at increased cardiovascular risk (ACHIEVE-4): a phase 3, event-driven, randomised, open-label, non-inferiority, active comparator trial
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| Natural Products | Discovery and Bioinspired Synthesis of Neuroprotective Geranylated Chalcones From Artocarpus communis
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| Food, Nutrition & Regulation | Ultra-processed food consumption and risk of multiple chronic diseases among 8,819,894 adults from 51 prospective cohorts: a dose-response meta-analysis
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| Food, Nutrition & Regulation | Mycotoxins and plant alkaloids in plant-based protein foods and meat alternatives: Occurrence, exposure and risk assessment
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| Food, Nutrition & Regulation | Safety of synthetic cannabidiol as a novel food pursuant to regulation (EU) 2015/2283
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| Food, Nutrition & Regulation | Re-evaluation of salt of aspartame-acesulfame (E 962) as food additive
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| Life Science Frontier | Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types
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| Natural Products | Canalesolide A, a Structurally Unique Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania sp. with Potent Antitrypanosomal Activity
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| Metabolism & Aging | A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan
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| Natural Products | Complete biosynthesis of the clinical agent escin Ia
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| Natural Products | Biodiversity as the Basis for New Drugs (논문: Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota)
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| Clinical Research | Obinutuzumab β for aquaporin-4-positive neuromyelitis optica spectrum disorder: a phase 3 randomized controlled trial
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| Natural Products | Population genomics reveals ginseng domestication and ginsenoside biosynthesis
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| Clinical Research | Bispecific Antibody Ivonescimab Added to Chemotherapy in EGFR-Variant Non-Small Cell Lung Cancer: The HARMONi-A Randomized Clinical Trial
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| Natural Products | Natural compound may fight rheumatoid arthritis at its source (논문: Obakulactone Alleviates Rheumatoid Arthritis by Promotion of ACOT1 Degradation via the Ubiquitin‒Proteasome Pathway and Restoration of Unsaturated Fatty Acid Homeostasis)
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| Food, Nutrition & Regulation | FDA Takes Further Steps to Remove Outdated Authorizations for Color Additives in Food
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| Metabolism & Aging | Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort
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| Natural Products | Cephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis
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| Food, Nutrition & Regulation | Carcinogenicity of butyl benzyl phthalate, dibutyl phthalate, and diisononyl phthalate
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| Life Science Frontier | Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production
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| Natural Products | Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
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| Life Science Frontier | Megabase-scale human genome rearrangement with programmable bridge recombinases
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| Natural Products | Leveraging antibiotic hormesis for cryptic natural product discovery
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| Brain & Mind | A Ketogenic Diet for Treatment-Resistant Depression: A Randomized Clinical Trial
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| Life Science Frontier | Customizing CRISPR-Cas PAM specificity with protein language models
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| Metabolism & Aging | Heritability of intrinsic human life span is about 50% when confounding factors are addressed
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| Life Science Frontier | A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor
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| Natural Products | Marine natural products
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| Food, Nutrition & Regulation | Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation: The DECAF Randomized Clinical Trial
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| Natural Products | Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial
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| Food, Nutrition & Regulation | Carcinogenicity of atrazine, alachlor, and vinclozolin
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| Food, Nutrition & Regulation | Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis
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| Brain & Mind | Physical activity as a modifiable risk factor in preclinical Alzheimer's disease
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| Natural Products | The total synthesis of (−)-spiroaspertrione A: A divinylcyclopropane rearrangement approach
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| Natural Products | Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study
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| Clinical Research | Effect of BCG Danish and oral polio vaccine on neonatal mortality in newborn babies weighing less than 2000 g in India: multicentre open label randomised controlled trial (BLOW2)
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| Natural Products | Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1
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| Clinical Research | Aficamten or Metoprolol Monotherapy for Obstructive Hypertrophic Cardiomyopathy
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| Natural Products | Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension
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| Natural Products | Aurantii Fructus alleviates depression via modulating hippocampal caspase-4-linked neurogenesis and synaptic plasticity in mice
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| Brain & Mind | Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial
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| Brain & Mind | A gut sense for a microbial pattern regulates feeding
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| Metabolism & Aging | NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
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| Food, Nutrition & Regulation | Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials
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| Food, Nutrition & Regulation | High diversity of dietary flavonoid intake is associated with a lower risk of all-cause mortality and major chronic diseases
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| Metabolism & Aging | Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging
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| Natural Products | Elucidation of the biosynthetic pathway of hydroxysafflor yellow A
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| Metabolism & Aging | Phase 3 Trial of Semaglutide in Metabolic Dysfunction-Associated Steatohepatitis
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| Metabolism & Aging | Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes
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| Brain & Mind | Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial
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| Natural Products | A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
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| Food, Nutrition & Regulation | Optimal dietary patterns for healthy aging
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| Life Science Frontier | Simulating 500 million years of evolution with a language model
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| Food, Nutrition & Regulation | Bioaccumulation of microplastics in decedent human brains
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| Food, Nutrition & Regulation | Assessing the Efficacy of Pyrolysis-Gas Chromatography-Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood
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| Metabolism & Aging | Mapping the effectiveness and risks of GLP-1 receptor agonists
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| Food, Nutrition & Regulation | FDA to Revoke Authorization for the Use of Red No. 3 in Food and Ingested Drugs
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| Clinical Research | Nationwide real-world implementation of AI for cancer detection in population-based mammography screening
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| Natural Products | Pattern-Based Genome Mining Guides Discovery of the Antibiotic Indanopyrrole A from a Marine Streptomycete
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| Natural Products | Total biosynthesis of the medicinal triterpenoid saponin astragalosides
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| Metabolism & Aging | Metformin decelerates aging clock in male monkeys
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| Natural Products | The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial
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| Clinical Research | Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women
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| Metabolism & Aging | Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
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| Natural Products | Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities: The FOCUS Randomized Clinical Trial
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| Food, Nutrition & Regulation | Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts
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| Food, Nutrition & Regulation | Tampons as a source of exposure to metal(loid)s
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| Life Science Frontier | Paternal and induced gut microbiota seeding complement mother-to-infant transmission
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| Food, Nutrition & Regulation | Xylitol is prothrombotic and associated with cardiovascular risk
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| Natural Products | Anti-adipogenic and anti-obesity effects of morroniside in vitro and in vivo
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| Brain & Mind | Brain clearance is reduced during sleep and anesthesia
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| Life Science Frontier | Accurate structure prediction of biomolecular interactions with AlphaFold 3
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| Natural Products | Complete biosynthesis of QS-21 in engineered yeast
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| Clinical Research | Exagamglogene Autotemcel for Severe Sickle Cell Disease
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| Food, Nutrition & Regulation | PFAS National Primary Drinking Water Regulation
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| Brain & Mind | Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability
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| Metabolism & Aging | Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis
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| Clinical Research | A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening
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| Food, Nutrition & Regulation | Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women: Postintervention Follow-up of a Randomized Clinical Trial
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| Food, Nutrition & Regulation | Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
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| Clinical Research | RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial
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| Natural Products | Efficacy and safety of Shenbai Granules for recurrent colorectal adenoma: A multicenter randomized controlled trial
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| Metabolism & Aging | Long-Term Outcomes of Medical Management vs Bariatric Surgery in Type 2 Diabetes
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| Life Science Frontier | scGPT: toward building a foundation model for single-cell multi-omics using generative AI
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| Brain & Mind | Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests
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| Clinical Research | Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
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| Food, Nutrition & Regulation | Effect of a Salt Substitute on Incidence of Hypertension and Hypotension Among Normotensive Adults
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| Natural Products | Effect of cinnamon spice on continuously monitored glycemic response in adults with prediabetes: a 4-week randomized controlled crossover trial
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| Natural Products | Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III
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| Metabolism & Aging | Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
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| Food, Nutrition & Regulation | Dietary protein intake in midlife in relation to healthy aging - results from the prospective Nurses' Health Study cohort
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| Natural Products | Inhibitory Effects of Loganin on Adipogenesis In Vitro and In Vivo
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| Metabolism & Aging | Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice
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| Clinical Research | Efficacy and Safety of Combined Extracts of Cornus officinalis and Ribes fasciculatum for Body Fat Reduction in Overweight Women
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| Natural Products | Antiadipogenic Effects of Mixtures of Cornus officinalis and Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Mice
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