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Explainers

Safety & Standards
Natural Products | Bioactivity | Metabolism & Aging | Safety & Standards

Safety & Standardization

The composition of nature-derived materials can vary with biological origin, growing conditions, harvest time and processing. Accurate authentication, consistent quality and sound safety assessment are therefore prerequisites for reproducible research, supported by reporting standards such as the ConPhyMP guidelines for extract characterization.

Key topics

  • 01
    Authentication

    Morphological identification and DNA barcoding

  • 02
    Quality standardization

    Marker compounds and chemical fingerprints

  • 03
    Method validation

    Specificity, linearity, accuracy, precision, LOD/LOQ

  • 04
    Contaminants

    Heavy metals, pesticides, mycotoxins, microbes

  • 05
    Toxicology

    Single- and repeated-dose and genotoxicity studies

  • 06
    Interactions & adverse events

    Drug interactions and safety monitoring

This page describes the field in general terms and makes no claims about specific ingredients or products.

References
  1. Heinrich M, Jalil B, Abdel-Tawab M, et al. Best practice in the chemical characterisation of extracts used in pharmacological and toxicological research — The ConPhyMP-Guidelines. Front Pharmacol 2022;13:953205.
  2. ICH(International Council for Harmonisation) Q2 — Validation of Analytical Procedures; ICH M3 — Nonclinical Safety Studies.
  3. OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects.