4-HBA
A marker compound of Ribes fasciculatum leaf and a subject of browning research
4-Hydroxybenzoic acid (4-HBA) is a phenolic acid of the hydroxybenzoic acid class. In cells it is made from tyrosine and serves as the starting material for the coenzyme Q10 ring, and in industry it is the parent compound of paraben esters.
It is used as a marker compound of Ribes fasciculatum (chilhaemok) leaf ingredients, and a cell and mouse study evaluating black raspberry-derived 4-HBA reported browning of white fat through the AMPK–DRP1 axis.
| Category | Phenolic acid (hydroxybenzoic acid) |
|---|---|
| Origin | Ribes fasciculatum leaf, black raspberry, and several other plants |
| In the body | Ring precursor in coenzyme Q10 biosynthesis |
| Role | Marker compound of the Ribes fasciculatum leaf ingredient |
| Level of research | Cell and mouse studies (increased UCP1 and PRDM16, AMPK–DRP1-dependent) |
The Cornus extract complex, which is managed using 4-HBA as a marker compound, has been commercialised by partner company ONDAM BIO as the consumer product “SANBIDAM Premium.”
Further reading
- “Notified” vs. “Individually Approved”: Two Routes by Which Health Functional Food Ingredients Are Recognised Analysis
- Adults Have Brown Fat Too: The PET-CT Analysis That Changed How Metabolism Is Studied Analysis
- 4-Hydroxybenzoic Acid: From the Backbone of Parabens to Research on Fat Browning Analysis
- SANBIDAM Premium: An Ingredient From an Ajou University Subsidiary With Loganin and 4-HBA as Marker Compounds Feature
- A Single Bottle a Day Instead of Pills: The Liquid Design of SANBIDAM Premium Feature
- ONDAM BIO's SANBIDAM Premium: Five Criteria for Choosing an Ingredient Developed by an Ajou University Subsidiary Feature
- Black Raspberry Component 4-HBA Found to Drive 'Browning' of White Fat: Mouse Study News
- Cornus and Ribes fasciculatum Complex Extract Curbs Weight Gain in Obese Mice at Three Doses News
- Cornus and Ribes fasciculatum Complex Extract Reduces Body Fat in 12-Week Trial in Overweight Women News
- Cornus and Ribes fasciculatum 7:3 Blend Suppresses Fat Cell Differentiation More Than Either Alone News
Other topics: Resistant maltodextrin · Cornus extract complex · Loganin
References
- Kim SH, et al.. 4-hydroxybenzoic acid induces browning of white adipose tissue through the AMPK-DRP1 pathway in HFD-induced obese mice. Phytomedicine. DOI: 10.1016/j.phymed.2024.156353
- Lee Y, et al.. Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling. Molecules. DOI: 10.3390/molecules27051649