Brain Science & Mental Health

In a randomised trial in the U.K., the ketogenic diet lowered depression scores slightly more than a healthy control diet, but the clinical meaning was uncertain.

In cognitively normal older adults with high amyloid levels, more steps were associated with slower tau accumulation and slower cognitive decline, an observational finding.

In a randomised trial of 2,111 older Americans, an intensive structured program produced a slightly larger gain in overall cognition.

A circuit in mice was identified in which sensory cells in the colon detect flagellin from gut bacteria and reduce food intake through the vagus nerve.

Among carriers of familial Alzheimer's mutations, the group given gantenerumab for longer showed a trend towards lower risk of symptom progression.

In a Rush University cohort in the United States, the most socially active older adults were predicted to develop dementia about five years later than the least active.

Individualised precision brain mapping showed that the frontostriatal salience network was markedly expanded in people with depression compared with healthy people.

Mouse brains cleared less of an injected fluorescent tracer when asleep or anaesthetised than when awake.

In an analysis of 2.48 million Swedish children, no association was found between acetaminophen use in pregnancy and neurodevelopmental disorders once sibling-control analysis was applied.

A plasma p-tau217 ratio test found Alzheimer's pathology as accurately as an FDA-cleared cerebrospinal fluid test and was better at identifying tau.